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Papaya Seed Essential Oil Anti-Acne Cream and Its Effectiveness Against Staphylococcus epidermidis and Cutibacterium acnes
Abstract
Acne is a common skin disorder that affects people from all walks of life. One of the causes of acne is the bacteria Staphylococcus epidermidis and Cutibacterium acne. Papaya seeds are known to have antibacterial properties because they contain active compounds that inhibit bacterial growth. The main objective of this study was to determine the antibacterial activity of acne cream with the addition of papaya seed essential oil (Carica papaya L.) against Staphylococcus epidermidis and Cutibacterium acne bacteria. The method used in the production of essential oil was steam distillation, the antibacterial activity test was conducted using the disc diffusion method with concentrations of 10%, 20%, 30%, 40%, and 50%, and the cream activity test was conducted using the well method. The data analysis results were analyzed using analysis of variance (ANOVA). The results showed that papaya seed essential oil against Staphylococcus epidermidis bacteria at concentrations of 10%, 20%, 30%, 40%, and 50% was 7.7 mm, 13.1 mm, 16.3 mm, 18.7 mm, and 21.6 mm, respectively. Meanwhile, against Cutibacterium acne, the results were 4.6 mm, 6.4 mm, 9.9 mm, 12.1 mm, and 14.1 mm, respectively. Meanwhile, the inhibition zone results of papaya seed essential oil cream against Staphylococcus epidermidis bacteria at concentrations of 40% and 50% were 18.7 mm and 21.7 mm, respectively, while the inhibition zone of the cream against Cutibacterium acne bacteria was 12.8 mm and 14.1 mm. It can be concluded that the acne cream made from papaya seed essential oil has the potential to inhibit the growth of Staphylococcus epidermidis and Cutibacterium acne. A concentration of 50% proved to be the most effective in inhibiting the growth of acne-causing bacteria.
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Ahmad, F. F., Jangga, & Hasnaeni. (2023). Pemanfaatan Ektrak Biji Pepaya ( Carica papaya L ) Sebagai Antiacne Dalam Bentuk Sediaan Maker Peel-off. Journal of Pharmaceutical Science and HerbalTechnology, 1(1), 40–48.
Amin, S. S., Ghozali, T. Z., & Efendi, M. R. S. (2023). Identifikasi Bakteri dari Telapak Tangan dengan Pewarnaan Gram. Chemviro : Jurnal Kimia Dan Ilmu Lingkungan, 1(1), 30–35. https://doi.org/10.56071/chemviro.v1i1.563
Anief, M. (2007). Ilmu Meracik Obat. Gadjah Mada University Press.
Ardhany, S. D., Effendie, R. R., & Novaryatiin, S. (2019). Uji Iritasi Formulasi Sediaan Krim Ekstrak Bawang Dayak (Eleutherine bulbosa (Mill.) Urb) pada Kelinci Albino Putih. Jurnal Surya Medika, 5(1), 63–69. https://doi.org/10.33084/jsm.v5i1.946
Ardian. (2021). Ensiklopedi Anatomi Tumbuhan. Hitam Pustaka.
Ardiansyah, R. (2009). Jadi kaya dengan pepaya. JP Books.
Asni, N. K., & Sianita, M. M. (2020). Pengaruh Jumlah Crosslinker Terhadap Persen Ekstraksi Pada Sintesis Moleculary Imprinted Polymer Sebagai Adsorben Untuk Kloramfenikol. 2507(February), 1–9.
Aviany, H. B., & Pujiyanto, S. (2020). Analisis Efektivitas Probiotik di dalam Produk Kecantikan sebagai Antibakteri terhadap Bakteri Staphylococcus epidermidis. Jurnal Berkala Bioteknologi, 3(2), 24–31.
Cappuccino, J., & Sherman. (2014). Manual Laboratorium Mikrobiologi Edisi Kedelapan. EGC.
Dalimartha, S. (2009). Atlas Tumbuhan Obat Jilid 6. Puspa swara.
Fathanah, U., Razi, F., Lubis, M. R., Yusuf, M., Syamsuddin, Y., Meilina, H., Muchtar, S., Kamaruzzaman, S., & Khairunnisa, A. (2022). Modifikasi Membran Polyethersulfone dengan Penambahan Nanopartikel Mg(OH)2 dalam Pelarut Dimethyl Sulfoxide. ALCHEMY Jurnal Penelitian Kimia, 18(2), 165. https://doi.org/10.20961/alchemy.18.2.58248.165-173
Febriani, A., Maruya, I., & Sulistyaningsih, F. (2020). Formulasi dan Uji Iritasi Sediaan Gel Kombinasi Ekstrak Etanol Rimpang Kencur (Kaempferia galanga L.) dan Ekstrak Etanol Herba Pegagan (Centella asiatica (L.) Urban) Formulation and Irritation Test of Gel Combination of Galangal Rhizome (Kaempferia galang. Jurnal Ilmu Kefarmasian, 13(1), 45–54.
Hainil, S., Sammulia, S. F., & Adella, A. (2022). Aktivitas Antibakteri Staphyloccocos aureus dan Salmonella thypi Ekstrak Metanol Anggur Laut (Caulerpa racemosa). Jurnal Surya Medika, 7(2), 86–95. https://doi.org/10.33084/jsm.v7i2.3210
Hamka, Z., & Hardiyanty, S. (2021). Formulasi Dan Uji Efektivitas Sediaan Krim Minyak Nilam Terhadap Propionibacterium acne. Jurnal Kesehatan Yamasi, 5(1), 112–114.
Hardiyanto, D., & Soegiantoro. (2023). Pengantar Ilmu Resep Dalam Perspektif Teologi Kristen. PT.Scifintech Andrew Wijaya.
Hotmian, E., Suoth, E., Fatimawali, F., & Tallei, T. (2021). Analisis GC-MS (GAS CHROMATOGRAPHY - MASS SPECTROMETRY) Ekstrak Metanol Dari Umbi Rumput Teki (Cyperus rotundus L.). Pharmacon, 10(2), 849. https://doi.org/10.35799/pha.10.2021.34034
Kurnia, R. (2018). Fakta Seputar Pepaya. Bhuana Ilmu Populer.
Kurniaty, R., Ainun, A., Farida, M., Azhari, S., Salman, & Mahmudi, M. (2021). Formulasi Dan Uji Efektivitas Sediaan Krim Minyak Nilam (Pogestemon cablin, Benth) Terhadap Propionibacterium acnes. Journal.Yamasi.Ac.Id, 5(1), 112–124. http://
Magne, J., Guy, J., & Maynadié, M. (2015). Hematology. In Revue Francophone des Laboratoires (Vol. 2015, Issue 471). https://doi.org/10.1016/S1773-035X(15)30080-0
Magvirah, T., Marwati, M., & Ardhani, F. (2020). Uji Daya Hambat BakteriStaphylococcus Aureus Menggunakan Ekstrak Daun Tahongai (Kleinhovia hospitaL.). Jurnal Peternakan Lingkungan Tropis, 2(2), 41. https://doi.org/10.30872/jpltrop.v2i2.3687
Mardiyantoro, F., Munika, K., & Sutanti, V. (2018). Penyembuhan Luka Rongga Mulut. UB Press.
Pariury, J. A., Juan Paul Christian Herman, Tiffany Rebecca, Elvina Veronica, & I Gusti Kamasan Nyoman Arijana. (2021). Potensi Kulit Jeruk Bali (Citrus Maxima Merr) Sebagai Antibakteri Propionibacterium acne Penyebab Jerawat. Hang Tuah Medical Journal, 19(1), 119–131. https://doi.org/10.30649/htmj.v19i1.65
Pelen, S., Wullur, A., & Citraningtyas, G. (2016). Formulasi Sediaan Gel Antijerawat Minyak Atsiri Kulit Batang Kayu Manis (Cinnamomum Burmanii) Dan Uji Aktivitas Terhadap Bakteri Staphylococcus Aureus. Jurnal Ilmiah Farmasi, 5(4), 159245. https://www.neliti.com/publications/159245/
Pratasik, M. C. M., Yamlean, P. V. Y., & Wiyono, W. I. (2019). Formulasi Dan Uji Stabilitas Fisik Sediaan Krim Ekstrak Etanol Daun Sesewanua (Clerodendron squamatum Vahl.). Pharmacon, 8(2), 261. https://doi.org/10.35799/pha.8.2019.29289
Rahayu, Y. P., Lubis, M. S., & Mutti-in, K. (2020). Formulasi Sediaan Sabun Cair Antiseptik Ekstrak Biji Pepaya (Carica Papaya L.) Dan Uji Efektivitas Antibakterinya Terhadap Staphylococcus Aureus. Prosiding Seminar Nasional Hasil Penelitian, 373–388. https://www.e-prosiding.umnaw.ac.id/index.php/penelitian/article/view/774/749
Rosmania, R., & Yanti, F. (2020). Perhitungan jumlah bakteri di Laboratorium Mikrobiologi menggunakan pengembangan metode Spektrofotometri. Jurnal Penelitian Sains, 22(2), 76. https://doi.org/10.56064/jps.v22i2.564
Sari, A. K., & Hanistya, R. (2023). Farmasetika Sediaan Semisolida. Rena Cipta Mandiri.
Satriyasa, B. K., & Pangkahila, W. I. (2010). Fraksi heksan dan fraksi metanol ekstrak biji pepaya muda menghambat spermatogonia mencit jantan. Jurnal Veteriner, 11(1).
Sefriyanti, Jayuska, A., & Alimuddin, A. H. (2020). Uji Aktivitas Antibakteri Minyak Atsiri Sereh Wangi ( Cymbopogon bernadus L .) terhadap Bakteri Escherichia coli dan Staphylococcus aureus. Jurnal Kimia Khatulistiwa, 8(4), 1–4.
Sifatullah, N., & Zulkarnain. (2021). Jerawat (Acne vulgaris): Review Penyakit Infeksi Pada Kulit. Prosiding Biologi Achieving the Sustainable Development Goals , November, 19–23. http://journal.uin-alauddin.ac.id/index.php/psb
Siswantito, F., Natasya, A., Nugroho, R., Listiarini Iskandar, R., Sitanggang, C. O., Al-Qordhiyah, Z., Rosidah, C., Nurhayati, S., Sari, A., & Karawang, S. (2023). Produksi Minyak Atsiri melalui Ragam… (Siswantito, dkk) 178 Produksi Minyak Atsiri Melalui Ragam Metode Ekstraksi Dengan Berbahan Baku Jahe. Inovasi Teknik Kimia, 8(3), 178–184.
Syamsuni. (2006). Farmasetika Dasar Dan Hitungan Farmasi. Penerbit Buku Kedokteran EGC.
Syarifah, F. (2015). Formula edible film ekstrak biji pepaya dan uji aktivitasnya terhadap bakteri klebsiela penumonia dan Staphylococcus aureus. Prosiding Penelitian SPeSIA Unisba.
Tania, A. D., Suoth, E. J., Fatimawali, & Tallei, T. E. (2021). Identification Of Chemical Coumpound In Nut Grass (Cyperus rotundus L.) Tuber N-Hexane Extract By GC-MS Analisis. Pharmacon, 10(3), 975–985.
DOI: https://doi.org/10.14421/biomedich.2025.142.1607-1616
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